![]() "The effect in the single patient is quite impressive, but, of course, the next crucial step is to test this approach in a larger cohort of patients," they wrote. He regularly takes walks spanning several kilometers at a time.Ī key innovation of this study was its customized modulation of dorsal roots in the lumbosacral spine, Mizrahi-Kliger and Ganguly noted. Two years later, he uses his neuroprosthetic device for about 8 hours a day, turning it off when he sits for long periods or sleeps. After several weeks of rehabilitation, the patient walked almost normally. When the patient wanted to walk, he used a remote control to send signals to the stimulator to activate leg neurons. "They become increasingly prevalent as the disease progresses they affect the majority of patients with late-stage Parkinson's disease and dominate the clinical presentation at 15 years after diagnosis," they wrote. ![]() "The idea of developing a neuroprosthetic that stimulates the spinal cord electrically to harmonize the procedure and correct locomotor disorders in patients with Parkinson's is the result of several years of research on the treatment of paralysis due to spinal cord injuries," Courtine said in a news briefing.īalance and gait impairments are hallmark symptoms of Parkinson's disease, noted Aviv Mizrahi-Kliger, MD, PhD, and Karunesh Ganguly, MD, PhD, both of the University of California San Francisco, in an editorial accompanying the research. Last year, Courtine and colleagues used EES to restore the ability to walk in a man with paralysis due to spinal cord injury. Targeting dorsal roots with epidural electrical stimulation (EES) modulates the activity of neurons that control walking movements. Freezing of gait, a Parkinson's symptom that had burdened the patient, nearly vanished when he used the neuroprosthesis.
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